Olive Oil Key Ingredient in Alzheimer’s Prevention? – Health Fitness, Diets, Weight Loss

Olive Oil Key Ingredient in Alzheimer’s Prevention?

Pam Harrison
Medscape Medical Information

Additional-virgin olive oil (EVOO) seems to guard reminiscence and studying skill and reduces the formation of beta amyloid (Aβ) plaques and neurofibrillary tangles within the mind — the basic hallmarks of Alzheimer’s illness (AD) — new animal analysis reveals.

The research, carried out by investigators at Temple College in Philadelphia, suggests that it’s the olive oil element of the Mediterranean food regimen that probably promotes wholesome mind getting old.

“Our research is the primary demonstration that EVOO can beneficially have an effect on reminiscence, amyloid plaques, and tau pathology, the hallmark lesions within the mind of Alzheimer’s sufferers,” lead researcher Domenico Pratico, MD, professor of pharmacology and microbiology, Heart for Translational Drugs, Lewis Katz Faculty of Drugs, Temple College, advised Medscape Medical Information.

“And outcomes are vital sufficient to completely encourage individuals to eat higher quantities of EVOO. On condition that it’s been consumed for no less than 2000 years, I don’t anticipate any unintended effects,” he added.

Associated: The research was revealed on-line June 21 within the Annals of Medical and Translational Neurology.

‘Thrilling Discovering’

For the research, the investigators examined the possibly helpful results of EVOO on triple transgenic mice. These mice are particularly bred to develop key pathologic options of AD, together with amyloid plaques and neurofibrillary tangles.

The animals have been divided into two teams. One group acquired EVOO-enriched chow, and the opposite acquired common chow with out EVOO.

The olive oil was launched into the food regimen when the mice have been 6 months of age, earlier than they started to develop signs of AD.

At six months, all animals have been examined for his or her behavioral efficiency on a sequence of checks with a purpose to set up baseline competency.

“General, we didn’t observe any statistically vital distinction between the 2 teams of mice in the course of the research, apart from the ten month time-point when the handled mice had a better physique weight than untreated ones,” the investigators report.

The mice have been subjected to the identical behavioral checks at each 9 and 12 months of age, after which they have been euthanized and their brains have been examined for the presence of key pathologic options of AD.

The researchers confirmed that mice fed the EVOO-enriched food regimen carried out considerably higher at each 9 and 12 months on checks designed to evaluate working reminiscence, spatial reminiscence, and studying talents in contrast with mice fed common chow.

The researchers additionally discovered a statistically vital discount within the quantity of Aβ peptides deposited within the brains of the EVOO-treated animals in contrast with controls.

There was additionally a big discount within the phosphorylated types of tau in mice fed the EVOO-enriched chow in comparison with controls, though olive oil had no impact on complete tau ranges in the identical area of the mind.

The investigators additionally examined whether or not the enhancements in cognitive efficiency and mind pathology that have been noticed in EVOO-treated mice is likely to be the results of an enchancment in synaptic integrity.

As soon as once more, they discovered higher preservation within the integrity of the synapses between neurons in EVOO-fed mice in contrast with controls.

Moreover, there was a dramatic enhance in nerve cell autophagy activation in mind cells from the EVOO-fed animals in contrast with controls. Dr Pratico defined that autophagy is a mechanism by which cells digest proteins which are produced in extra or which are irregular.

On this specific animal mannequin, autophagy digests and removes each amyloid plaques and phosphorylated tau.

“That is an thrilling discovering for us,” Dr Pratico stated in an announcement.

“Because of the autophagy activation, reminiscence and synaptic integrity have been preserved, and the pathological results in animals in any other case destined to develop Alzheimer’s illness have been considerably lowered. It is a essential discovery, since we suspect {that a} discount in autophagy marks the start of Alzheimer’s illness.”

In mild of the truth that most sufferers are identified with AD when signs are already current, Dr Pratico and colleagues plan to judge the consequences of introducing the identical EVOO-enriched food regimen at a stage when mice have already developed plaques and tangles.

Promising Results

Requested by Medscape Medical Information to touch upon the research, Marta Zamroziewicz, PhD, College of Illinois Urbana-Champaign, stated the findings present promising results that EVOO has on the AD-like phenotype in a mouse mannequin.

“Replication in a human mannequin is required earlier than additional suggestions may be made for shoppers, and conclusions on the optimum dosage of extra-virgin olive oil can’t but be made,” she stated.

Nonetheless, the present analysis factors to a means ahead, whereby a number of teams are handled with various doses of EVOO.

“This work is required to first decide whether or not there are threshold results – that’s, what’s the minimal dose of olive oil wanted to show helpful results and whether or not there a dosage at which olive oil supplementation turns into poisonous,” stated Dr Zamroziewicz.

Dr Zamroziewicz and her crew beforehand reported that one sample of omega-3 polyunsaturated fatty acids (PUFAs) made up of α-linolenic acid (ALA), stearidonic acid (SDA), and eicosatrienoic acid (ETE) is linked to fluid intelligence, which signifies an individual’s skill to resolve issues they’ve by no means encountered earlier than.

The investigators urged that metabolic processing of n-3 PUFAs might confer neuroprotection as a result of ALA, SDA, and ETE both possess distinctive neuroprotective results or are transformed to eicosapentaenoic acid and, to a lesser extent, docosahexaenoic acid.

“Our work means that nuts, seeds, and oils might function an alternative choice to fish and fish oils by way of offering neuroprotective omega-3 PUFAs,” the crew famous.

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